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Role of Lipid Profile, Apolipoproteins, and Their Ratio for Prediction of Cardiovascular Disease in Essential Hypertension
Dubey R. 1, Baghel D. S. 1, Gaikwad K. 1, Rathore V. 1, Saxena R. 1, Ansari Y. M. 1
1 Shyam Shah Medical College, Rewa, India


Background and Aim of Study: Dyslipidemia is a risk factor for cardiovascular disease, and lipid metabolism changes are linked to essential hypertension. The aim of the study: to investigate the significance of lipid parameters, apolipoproteins, and their ratio in predicting cardiovascular disease among individuals with essential hypertension.
Material and Methods: 250 patients with essential hypertension and 250 healthy control subjects were enrolled in this case-control study and their serum lipids and apolipoproteins were analyzed. Differences between cases and controls were examined using independent sample t-test and, a p-value <0.05 was considered significant.
Results: In the essential hypertensive group, fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), apolipoprotein B100 (Apo B100) and Apo B100/Apo A1 ratio were increased significantly compared to control subjects. Essential hypertensive patients had significantly decreased levels of apolipoprotein A1 (Apo A1) and high-density lipoprotein cholesterol (HDL-C) compared to controls. Moreover, age, body mass index (BMI), FBG, TC, TG, LDL-C, and VLDL-C, as well as the Apo B100/Apo A1 ratio, were significantly positively correlated with both systolic blood pressure (SBP) and diastolic blood pressure (DBP), but HDL-C and Apo A1 were significantly negatively correlated in essential hypertensive subjects. There was a significant positive correlation between apo B100 and SBP in people with essential hypertension. Apo B100 and DBP showed a positive association, however, it was not statistically significant.
Conclusions: Essential hypertensive people with dyslipidemia and an elevated Apo B100/Apo A1 ratio are at an increased risk for the development of cardiovascular disease.



essential hypertension, dyslipidemia, apolipoproteins, cardiovascular disease, systolic blood pressure, diastolic blood pressure



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Information about the authors:

Dubey Rahul; Postgraduate Student, Department of Biochemistry, Shyam Shah Medical College, Rewa, India.

Baghel Drutpal Singh; Doctor of Philosophy in Medical Biochemistry, Professor, Department of Biochemistry, Shyam Shah Medical College, Rewa, India.

Gaikwad Kapila; MD, Associate Professor, Department of Biochemistry, Shyam Shah Medical College, Rewa, India.

Rathore Vedika (Corresponding Author) –; This email address is being protected from spambots. You need JavaScript enabled to view it.; Doctor of Philosophy in Medical Biochemistry, Associate Professor (Designated), Department of Biochemistry, Shyam Shah Medical College, Rewa, India.

Saxena Ravindra; Postgraduate Student, Department of Biochemistry, Shyam Shah Medical College, Rewa, India.

Ansari Yar Mohammad; Postgraduate Student, Department of Biochemistry, Shyam Shah Medical College, Rewa, India.

Cite this article as:


Dubey, R., Baghel, D. S., Gaikwad, K., Rathore, V., Saxena, R., & Ansari, Y. M. (2023). Role of lipid profile, apolipoproteins, and their ratio for prediction of cardiovascular disease in essential hypertension. International Journal of Science Annals, 6(1), 32–39.


Dubey, R., Baghel, D. S., Gaikwad, K., Rathore, V., Saxena, R., & Ansari, Y. M. 2023. "Role of lipid profile, apolipoproteins, and their ratio for prediction of cardiovascular disease in essential hypertension". International Journal of Science Annals, [online] 6(1), pp. 32–39. viewed 30 June 2023,


Dubey R., Baghel D. S., Gaikwad K., Rathore V., Saxena R., & Ansari Y. M. Role of lipid profile, apolipoproteins, and their ratio for prediction of cardiovascular disease in essential hypertension. International Journal of Science Annals [Internet]. 2023 [cited 30 June 2023]; 6(1): 32–39. Available from:

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