| 1 Shyam Shah Medical College, Rewa, India |
Abstract
Background and Aim of Study: Dyslipidemia is a risk factor for cardiovascular disease, and lipid metabolism changes are linked to essential hypertension. The aim of the study: to investigate the significance of lipid parameters, apolipoproteins, and their ratio in predicting cardiovascular disease among individuals with essential hypertension.
Material and Methods: 250 patients with essential hypertension and 250 healthy control subjects were enrolled in this case-control study and their serum lipids and apolipoproteins were analyzed. Differences between cases and controls were examined using independent sample t-test and, a p-value <0.05 was considered significant.
Results: In the essential hypertensive group, fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), apolipoprotein B100 (Apo B100) and Apo B100/Apo A1 ratio were increased significantly compared to control subjects. Essential hypertensive patients had significantly decreased levels of apolipoprotein A1 (Apo A1) and high-density lipoprotein cholesterol (HDL-C) compared to controls. Moreover, age, body mass index (BMI), FBG, TC, TG, LDL-C, and VLDL-C, as well as the Apo B100/Apo A1 ratio, were significantly positively correlated with both systolic blood pressure (SBP) and diastolic blood pressure (DBP), but HDL-C and Apo A1 were significantly negatively correlated in essential hypertensive subjects. There was a significant positive correlation between apo B100 and SBP in people with essential hypertension. Apo B100 and DBP showed a positive association, however, it was not statistically significant.
Conclusions: Essential hypertensive people with dyslipidemia and an elevated Apo B100/Apo A1 ratio are at an increased risk for the development of cardiovascular disease.
Keywords
essential hypertension, dyslipidemia, apolipoproteins, cardiovascular disease, systolic blood pressure, diastolic blood pressure
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Dubey Rahul – https://orcid.org/0009-0001-2123-9470; Postgraduate Student, Department of Biochemistry, Shyam Shah Medical College, Rewa, India.
Baghel Drutpal Singh – https://orcid.org/0009-0007-8078-7454; Doctor of Philosophy in Medical Biochemistry, Professor, Department of Biochemistry, Shyam Shah Medical College, Rewa, India.
Gaikwad Kapila – https://orcid.org/0000-0002-4265-936X; MD, Associate Professor, Department of Biochemistry, Shyam Shah Medical College, Rewa, India.
Rathore Vedika (Corresponding Author) – https://orcid.org/0000-0001-9803-7052;
Saxena Ravindra – https://orcid.org/0000-0003-2655-8531; Postgraduate Student, Department of Biochemistry, Shyam Shah Medical College, Rewa, India.
Ansari Yar Mohammad – https://orcid.org/0009-0004-6371-9984; Postgraduate Student, Department of Biochemistry, Shyam Shah Medical College, Rewa, India.
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APA
Dubey, R., Baghel, D. S., Gaikwad, K., Rathore, V., Saxena, R., & Ansari, Y. M. (2023). Role of lipid profile, apolipoproteins, and their ratio for prediction of cardiovascular disease in essential hypertension. International Journal of Science Annals, 6(1), 32–39. https://doi.org/10.26697/ijsa.2023.1.3
Harvard
Dubey, R., Baghel, D. S., Gaikwad, K., Rathore, V., Saxena, R., & Ansari, Y. M. 2023. "Role of lipid profile, apolipoproteins, and their ratio for prediction of cardiovascular disease in essential hypertension". International Journal of Science Annals, [online] 6(1), pp. 32–39. viewed 30 June 2023, https://culturehealth.org/ijsa_archive/ijsa.2023.1.3.pdfVancouver
Dubey R., Baghel D. S., Gaikwad K., Rathore V., Saxena R., & Ansari Y. M. Role of lipid profile, apolipoproteins, and their ratio for prediction of cardiovascular disease in essential hypertension. International Journal of Science Annals [Internet]. 2023 [cited 30 June 2023]; 6(1): 32–39. Available from: https://culturehealth.org/ijsa_archive/ijsa.2023.1.3.pdf https://doi.org/10.26697/ijsa.2023.1.3
